MILWAUKEE (Interstat) — The Milwaukee Brewers, owners of the best record in the National League, open a three-game series Tuesday night against the last-place San Francisco Giants at American Family Field. Right-hander Trevor McDonald (2-2) is scheduled to start for San Francisco, which is listing ace left-hander Kyle Harrison (6-1) as a probable pitcher but appears to be employing a bullpen game or tandem approach. The Giants (23-36) have lost seven of their last 10 games, though they erupted for a season-high 19 runs in a win Sunday at Colorado. First pitch is set for 7:40 p.m. CDT under cloudy skies with a temperature of 65 degrees, though the retractable roof at the ballpark will likely remain closed. Milwaukee (35-21) counters with right-hander Jacob Misiorowski, who has been dominant over his past three starts. The 24-year-old is 3-0 in that span with a 0.00 ERA over 20 innings, striking out 28 batters while allowing just eight hits and one earned run. He threw seven shutout innings in a 2-0 win at Houston on Sunday, scattering three hits with eight strikeouts. The Brewers are 14 games above .500 and have won seven of their last 10, including a 2-2 tie with the Giants on Monday in the series opener — a game that was called after nine innings due to a league-mandated curfew. Milwaukee’s pitching staff has been the club’s backbone, posting a 2.83 ERA over the last week. San Francisco’s offense is led by rookie first baseman/designated hitter Bryce Eldridge, who is hitting .364 (8-for-22) over his last six games with one home run and three RBIs. He went 4-for-6 with a homer and an RBI in Sunday’s win over the Rockies. Milwaukee’s offense has been more balanced, but the club has struggled to score consistently against elite pitching. The Brewers are averaging 4.7 runs per game on the season but have been held to two or fewer runs in three of their last eight contests. The Interstat game simulator projects a 6-3 Milwaukee victory. The Brewers are a -1.5 favorite on the run line, with the over/under set at 7.5 runs. Following Tuesday’s game, the teams meet again Wednesday and Thursday in Milwaukee before the Giants travel to Chicago to face the Cubs and the Brewers head to Colorado.