SAN DIEGO (Interstat) — The Philadelphia Phillies and San Diego Padres continue their three-game series Wednesday evening at PETCO Park, with first pitch set for a cloudy 67-degree night. Philadelphia (27-27) and San Diego (31-22) both maintain division aspirations, but enter this matchup on opposite trajectories. The Phillies have lost four of their last six games, while the Padres are coming off a series win over Oakland after dropping two straight contests to the Phillies. The pitching matchup features uncertainty for Philadelphia. The Phillies list both left-hander Cristopher Sánchez (5-2) and right-hander Walker Buehler (3-2) as probable starters, though Sánchez has been the more consistent option this season. Players to watch Philadelphia: Jesús Luzardo. The left-hander has been dominant in his last three outings, posting a 0.00 ERA with 15 strikeouts over 18 innings. In Monday’s series opener, Luzardo tossed six shutout innings, allowing four hits while striking out six. His only recent blemish came May 8 against Colorado, when he allowed six earned runs in three innings. San Diego: Griffin Canning. The right-hander has struggled mightily, losing three consecutive starts while posting a 9.00 ERA over those 11 innings. Canning took the loss Monday against these same Phillies, surrendering three earned runs on three hits in 6 2/3 innings. He has not recorded a win since May 3, when he limited the Chicago White Sox to one run over five innings. Recent history Philadelphia won the series opener 3-0 on Monday, with Luzardo earning the victory. Brandon Marsh provided the offensive punch with a home run and two RBIs. The Phillies took the second game 3-0 on Tuesday. The Padres have dropped four of their last six games, while the Phillies snapped a four-game losing streak with Monday’s victory. By the numbers The Interstat game simulator projects a 6-5 Padres victory. Philadelphia opened as a -1.5 run favorite, and the over/under is 7.5 runs. San Diego holds a four-game lead in the NL West and will look to rebound before embarking on a three-game series at Washington starting Friday. The Phillies remain at .500 and travel to Los Angeles for three games against the Dodgers this weekend.