ATLANTA (Interstat) — Michael Penix Jr. threw three touchdown passes and Nick Folk kicked three field goals, helping the Atlanta Falcons hold off the San Francisco 49ers 29-20 on Sunday at Mercedes-Benz Stadium. Attendance was 72,165. Atlanta improved to 3-4 and snapped a two-game losing streak. San Francisco fell to 6-1 and lost for the first time this season. San Francisco opened the scoring when Christian McCaffrey scored on a 1-yard run and Eddy Pineiro added the extra point. Atlanta answered with Folk’s 39-yard field goal. Early in the second quarter, Kaelon Black broke free for a 30-yard touchdown run, and Pineiro’s extra point gave the 49ers a 14-3 lead. The Falcons trimmed the deficit when Penix found Nick Muse for a 1-yard touchdown, though Folk’s extra point hit the right upright and was no good. Folk added a 33-yard field goal as time expired in the half, pulling Atlanta within 14-12. Atlanta took the lead for good in the third quarter when Penix hit Kyle Pitts Sr. for a 5-yard touchdown and Folk converted. Penix then found Drake London for a 21-yard touchdown early in the fourth, extending the Falcons’ lead to 26-14. San Francisco appeared to answer with a deep pass from Brock Purdy to Jordan Watkins for a 23-yard touchdown, but the replay official reviewed the completion and reversed the call to incomplete. The reversal kept the score at 26-14. The 49ers later pulled within 26-20 when Purdy found Kyle Juszczyk for a 1-yard touchdown, but Pineiro’s extra point went wide left. That miss left San Francisco needing a touchdown. Folk’s 31-yard field goal with 1:56 remaining restored a nine-point lead, and the 49ers could not answer on their final possession. The replay reversal was one of the game’s pivotal moments. San Francisco had appeared to cut into the lead with a 23-yard scoring pass, but the incomplete ruling kept the 49ers behind by 12 points. San Francisco later moved within six on Juszczyk’s short touchdown catch, but Pineiro missed the extra point. Folk’s third field goal then made it a two-score game with less than two minutes remaining. Purdy completed 27 of 40 passes for 288 yards and one touchdown and ran twice for 5 yards. He was intercepted twice. Penix completed 25 of 34 passes for 213 yards and three touchdowns. San Francisco had entered as one of the league’s remaining unbeaten teams. The 49ers had won their first six games, including a 23-17 victory over Washington in their previous game. Atlanta had lost its previous two games to Chicago and Baltimore. The Falcons improved to 3-4 with the win. Malik Mustapha led San Francisco with eight tackles. Folk made all three field goals. Jake Bailey punted three times for 117 yards. Kaelon Black ran 12 times for 63 yards and a touchdown, added one catch for minus-4 yards and returned a kickoff 34 yards. McCaffrey had seven carries for 39 yards and six catches for 61 yards and a touchdown. Jacob Cowing had one run for 10 yards, three catches for 38 yards and a 28-yard kickoff return. Jordan James had four kickoff returns for 119 yards, one run for 6 yards and one catch for 11 yards. George Kittle caught eight passes for 88 yards to lead San Francisco. Jordan Watkins had three catches for 56 yards before his would-be touchdown was erased. Luke Farrell caught one pass for 14 yards and made a tackle. Brandin Cooks had one catch for 13 yards. Kyle Juszczyk caught three passes for 11 yards and a touchdown. Fred Warner made 13 tackles and Dre Greenlaw added 12. Christian Harris made one tackle for Atlanta. Deommodore Lenoir had six tackles, Jack Jones five, Ji’Ayir Brown five, Renardo Green four, James Thompson Jr. four, Ashtyn Davis two, Mykel Williams two, Jaden Dugger two and Romello Height two. Trent Williams, Eddy Pineiro, Jalen Graham, Osa Odighizuwa and Khalid Kareem each made one tackle. Corliss Waitman punted once for 37 yards. Xavier Watts made seven tackles for Atlanta. Bijan Robinson ran 20 times for 63 yards and caught five passes for 59 yards. Khalil Herbert had two runs for 9 yards, one catch for 19 yards and two kickoff returns for 65 yards. Zachariah Branch had one run for 8 yards, one catch for 9 yards and a 61-yard kickoff return. Charlie Woerner had one run for 3 yards and one catch for 9 yards. Drake London caught seven passes for 66 yards and a touchdown. Kyle Pitts Sr. had five catches for 22 yards and a touchdown. Austin Hooper caught two passes for 21 yards. Jahan Dotson had one catch for 6 yards. Nick Muse caught two passes for 2 yards and a touchdown and made one tackle. Gervon Dexter Sr. made two tackles. Kendal Daniels had 11 tackles and an interception. Harold Perkins Jr. made nine tackles. Jessie Bates III had nine tackles and an interception. C.J. Henderson made six tackles. Daniels and Bates accounted for Atlanta’s two interceptions. San Francisco’s defense was led by Warner and Greenlaw, while Mustapha added eight tackles. The 49ers also got six tackles from Lenoir, five from Jones and five from Brown. Atlanta’s defense got 11 tackles and an interception from Daniels, nine tackles from Perkins and nine tackles plus an interception from Bates. Henderson added six tackles, and Watts had seven. The Falcons held San Francisco to 20 points and forced two interceptions. The 49ers held Atlanta to 29 points and 213 passing yards. San Francisco will next host Las Vegas, and Atlanta will visit Tampa Bay. Interstat’s game simulator had projected a final score of San Francisco 37, Atlanta 31. Interstat’s ELO system had projected San Francisco with an 81.1 percent probability to win. San Francisco had been installed as a pregame favorite with a spread of minus-2.5. The total score of 49 went over the over-under line of 50.