SANTA CLARA, Calif. (Interstat) — A surging San Francisco 49ers squad will look to solidify its playoff positioning when it hosts the struggling Tennessee Titans at Levi’s Stadium on Sunday, Dec. 14, 2025. The 49ers (9-4) enter the contest riding a three-game winning streak, having outscored opponents 87-39 during that span. Quarterback Brock Purdy has been efficient, throwing for six touchdowns against zero interceptions in the last three victories. The San Francisco defense has been equally dominant, allowing an average of just 8.3 points per game in that stretch. Conversely, the Titans (2-11) are mired in a difficult season, though they are coming off a stunning 31-29 road victory over the Cleveland Browns. Rookie quarterback Cam Ward provided the spark, accounting for two rushing touchdowns in the win, which snapped a four-game losing skid. Ward’s dynamic dual-threat ability will be a focal point for the 49ers’ top-ranked defense. Despite Tennessee’s recent upset, the matchup presents a stark contrast. San Francisco boasts a balanced attack led by Purdy and running back Christian McCaffrey, while its defense ranks among the league’s best in scoring. The Titans have struggled with consistency, particularly on offense, where they have been held to 20 points or fewer in eight of their 11 losses. According to National Statistical’s game simulator, the 49ers are projected to win 33-21. Oddsmakers have installed San Francisco as a 12.5-point favorite, with an over/under of 44.5 points. For the Titans, the game represents another tough test in a season of rebuilding. For the 49ers, it is a critical opportunity to maintain momentum and secure a coveted postseason berth in the competitive NFC playoff picture. Kickoff is set for 1:25 p.m. PST.