Preview: Brewers at Tigers, April 22, 2026 DETROIT (Interstat) — The Detroit Tigers look to even their series with the Milwaukee Brewers on Wednesday at Comerica Park after dropping the opener. First pitch is scheduled for 6:40 p.m. EDT under cloudy skies with a game-time temperature near 71 degrees. The Brewers (12-9) took Tuesday’s series opener 3-1 behind strong pitching. They will turn to right-hander Chad Patrick (1-0) in the second game. Patrick will face a Tigers lineup that managed just four hits in the loss. Detroit (12-11) counters with right-hander Jack Flaherty. A player to watch for the Tigers, Flaherty is coming off an unusual no-decision in Boston where he allowed three hits and zero earned runs over 3 1/3 innings but was pulled after 76 pitches. His season has been inconsistent, mixing dominant outings like a 6-inning, one-run win over Kansas City on April 15 with shorter starts where command has eluded him. A key player for Milwaukee is hard-throwing righty Jacob Misiorowski. While not starting Wednesday, his recent performances highlight the Brewers’ pitching depth. In his last start Sunday in Miami, he struck out nine over five innings, allowing one earned run. He has recorded 42 strikeouts over 26 2/3 innings this season. Both teams arrive after recent splits on the road. The Brewers lost two of three in Miami before coming to Detroit, while the Tigers took two of three in Boston before Monday’s series-ending loss. According to National Statistical’s game simulator, the Tigers are projected to win 7-3. Detroit has been installed as a pregame favorite with a spread of -1.5. The over/under is set at 8 runs. Following Wednesday’s contest, the teams conclude their three-game set Thursday afternoon before Milwaukee heads home to face Pittsburgh and Detroit travels to Cincinnati.